Abstract
The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Cell Line
-
Cocaine / chemistry*
-
Drug Design
-
Heterocyclic Compounds, 3-Ring / chemical synthesis*
-
Heterocyclic Compounds, 3-Ring / pharmacology*
-
Humans
-
Molecular Structure
-
Structure-Activity Relationship
Substances
-
Heterocyclic Compounds, 3-Ring
-
Cocaine